Table 5.

Multivariate analysis with nested generalized linear models taking into account Bristol stool score, age, sex, and BMI. Reported effect sizes and P‐values after Dunn and chi‐squared tests, with P‐values corrected for multiple comparisons with Benjamini–Hochberg.

Genus	Comparison	N	Z‐score Dunn	Pcorr Dunn	SC	P	Pcorr
Butyricicoccus	PPMS–BMS	46	2.56	0.03	−1.83	0.020	0.030
	PPMS–RRMS_U	50	−2.99	0.01	−2.94	<0.001	0.003
	PPMS–HC	146	4.01	<0.001	2.93	<0.001	<0.001
	RRMS_I–BMS	44	2.50	0.03	−2.35	0.008	0.012
	RRMS_I–RRMS_U	48	−2.91	0.01	−2.54	0.002	0.004
	RRMS_I–HC	144	−3.86	<0.001	2.62	<0.001	0.002
Clostridium cluster IV	BMS–HC	140	4.32	<0.001	−3.26	<0.001	<0.001
	PPMS–HC	146	3.33	0.006	−1.92	0.002	0.005
	RRMS_U–HC	144	−3.02	0.012	−2.36	<0.001	0.002
Clostridium cluster XVIII	RRMS_U–BMS	44	−2.11	0.058	1.86	0.023	0.030
	RRMS_U–PPMS	50	−2.80	0.037	2.01	0.008	0.012
	RRMS_U–RRMS_I	48	−2.32	0.038	1.57	0.023	0.030
	RRMS_U–HC	144	−2.82	0.024	2.20	0.004	0.007
Gemmiger	BMS–HC	140	−2.30	0.081	1.57	0.034	0.041
	PPMS–HC	146	−2.92	0.027	−1.18	0.052	0.057
	RRMS_I–HC	144	−3.39	0.011	2.14	0.002	0.004
Methanobrevibacter	PPMS–RRMS_I	50	2.56	0.078	−1.70	0.045	0.051
	PPMS–HC	146	−3.65	0.004	−1.80	0.002	0.005
Parabacteroides	RRMS_I–RRMS_U	48	2.00	0.098	0.89	0.236	0.236
	RRMS_I–HC	144	2.44	0.004	−1.55	0.064	0.067
Sporobacter	BMS–HC	140	3.31	0.005	−2.29	0.003	0.006
	PPMS–HC	146	4.30	<0.001	−3.64	<0.001	<0.001
	RRMS_I–HC	144	3.75	0.001	−3.80	<0.001	<0.001
	RRMS_U–HC	144	2.99	0.010	−2.21	<0.001	0.002

HC, healthy controls (N = 120, including FGFP samples); PPMS, primary progressive multiple sclerosis (N = 26); BMS, benign multiple sclerosis (N = 20); RRMS_U, untreated active RRMS (N = 24); RRMS_I, interferon‐beta‐treated RRMS (N = 24); RRMS_R, RRMS during a relapse (N = 4); SC, standard coefficient (beta); P, uncorrected P‐value; Pcorr, P‐value corrected for multiple comparisons with Benjamini–Hochberg, FDR.