Table 2.
Idebenone factor is associated with VA stabilization/recovery in OPA1‐mutant DOA patients.
| Predictor | Crude Odds Ratio (95% CI) | P‐value | Adjusted Odds Ratio (95% CI) | P‐value |
|---|---|---|---|---|
| Idebenone | 3.70 (1.04–13.14) | 0.043 | 4.37 (1.01–18.9) | 0.049 |
| Gender (male) | 0.23 (0.05–1.1) | 0.06 | 0.22 (0.04–1.2) | 0.081 |
| Genetics (missense) | 1.80 (0.45–7.0) | 0.40 | 1.11 (0.21–5.8) | 0.905 |
| VA at baseline (logMAR) | 8.60 (1.1–68.3) | 0.04 | 7.40 (0.8–71.1) | 0.083 |
| Age at baseline | ||||
| 12 ≤ Age at baseline < 20 * , 1 | 1.70 (0.14–21.3) | 0.67 | 0.89 (0.05–15.9) | 0.939 |
| Age at baseline> 20 * , 1 | 0.69 (0.13–3.50) | 0.65 | 0.44 (0.06–3.40) | 0.435 |
| Observation time | ||||
| 2 ≤ Observation time < 6 2 | 1.02 (0.20–4.97) | 0.98 | 0.62 (0.10–3.82) | 0.611 |
| Observation time> 6 2 | 0.30 (0.06–1.40) | 0.12 | 0.16 (0.02–1.02) | 0.052 |
VA, best‐corrected‐visual acuity; logMAR, logarithm of the minimal angle of resolution; CI, Confidence Interval.
1
reference: age at baseline < 12 years.
2
reference: observation time < 2 years.