Table 1.
Participants’ demographic and clinical characteristics.
| Cohort | MS (3T & 7T) | HC (3T & 7T) | HC (3T only) | HC (7T only) |
|---|---|---|---|---|
| Mean age (± SD), years | 40.4 ± 15.5 | 39.1 ± 14.6 | 29.2 ± 7.3 | 30.4 ± 12.1 |
| Female/male ratio | 5/2 | 4/3 | 14/16 | 19/21 |
| Mean disease duration (± SD), years | 3.3 ± 2.9 | – | – | – |
| Median EDSS (range) | 1.0 (0–3.5) | – | – | – |
| Mean WML 3T (± SD) | 4.2 ± 5.6* | 1.3 ± 0.5 | 1 ± 0.5 | – |
| Mean WML 7T (± SD) | 4.7 ± 3.2* | 3.5 ± 4.9 | – | 1.1 ± 0.6 |
| mean BPV 3T (± SD) | 997864.7 ± 64028.9* | 1054107 ± 162264.1 | 1045867 ± 96468.9 | – |
| mean BPV 7T (± SD) | 949882.3 ± 68526.9* | 1045119.4 ± 142164 | – | 1018672.5 ± 86579.9 |
Chi‐square test compare was used to compare categorical variables (i.e., gender) across groups. ANOVA was used to compare continuous variables across groups. Asterisks indicate statistically significant values in MS when compared to those in HC. No differences in age and gender distributions were attested.
MS, multiple sclerosis; HC, healthy controls; EDSS, Expanded Disability Status Scale; WML, white matter lesions in ml; BPV, brain parenchymal volume in mm3.