Figure 3.

Quantitative MRI reveals demyelination and atrophy in ECD. (A) Purple demarcates white matter regions where fractional anisotropy (FA), mean diffusivity (MD), or radial diffusivity values were significantly different between patients (PT) and controls (CT) (P < 0.05). (B) Brain images were averaged for 15 ECD patients and 15 healthy controls, generating two image maps that were statistically compared on a voxel‐by‐voxel basis. Five clusters of gray matter volume loss were found in ECD patients compared to controls (P < 0.05) and are demarcated in various colors. These clusters are all located on the right hemisphere, within the middle frontal gyrus (1.356 mL/pink), insula and perirolandic cortex (0.699 mL/red), posterior‐parietal cortex (0.411 mL/green), orbitofrontal cortex (0.254 mL/yellow), and perirolandic cortex (0.004 mL/blue).