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Comparison of β-hairpin conformational stability using different HBS linkages. (A–C) Structures of HP7Δ-HBS peptides with olefin (HP7Δ-HBS), thioether (HP7Δ-teHBS), and disulfide (HP7Δ-dsHBS) HBS linkages, respectively. (D) Circular dichroism spectra of olefin (red), thioether (purple), and disulfide (yellow) HBS peptides.
