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. 2020 Apr 21;11:189. doi: 10.3389/fendo.2020.00189

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Copyright © 2020 Su, Zhang, Zheng, Wang, Zhu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IDH1 promoted cell migration and invasion and IDH1 knockout decreased cell migration and proliferation. (A) Cell migration and invasion of the REB and IDH1 KO REB cells were determined using Transwell and (B) the values in each group were shown as mean ± S.D. (C) Cell migration and invasion of the IDH1 KO REB cells transfected with vector, wildtype IDH1, or IDH1 R132C mutation plasmid and (D) the values in each group were shown as mean ± S.D. (E) qPCR was used to analyze the relative expressions of a panel of EMT relevant markers in IDH1 KO REB cells transfected with vector, wildtype IDH1 or IDH1 R132C mutation plasmid. Data were shown as mean ± S.D. **P < 0.01, ***P < 0.001; ns indicates no significance.