Table 3.
Association of MMR Proteins Expression with Clinicopathological Characteristics from CRC Patients
| Characteristics | MMR, n (%) | p-value | |
|---|---|---|---|
| dMMR, n=131 | pMMR, n=607 | ||
| Age, years | <0.001* | ||
| <50 | 37 (28.24) | 89 (14.66) | |
| ≥50 | 94 (71.76) | 518 (85.34) | |
| Sex | 0.845 | ||
| Male | 78 (59.54) | 355 (58.48) | |
| Female | 53 (40.46) | 252 (41.52) | |
| Tumor location | <0.001* | ||
| Left-sided colon | 33 (25.19) | 141 (23.23) | |
| right-sided colon | 60 (45.80) | 12 (1.98) | |
| Rectal | 38 (29.01) | 343 (56.51) | |
| Differentiated degree | 0.048* | ||
| Well or moderate | 94 (71.76) | 484 (79.74) | |
| Poor | 37 (28.24) | 123 (20.26) | |
| Distant metastasis | 0.418 | ||
| No | 123 (93.89) | 580 (95.55) | |
| Yes | 8 (6.10) | 27 (4.45) | |
| Histology type | 0.056 | ||
| Non-mucinous | 96(73.28) | 491(80.89) | |
| Mucinous | 35(26.72) | 116(19.11) | |
| Ki-67 (%) | 0.732 | ||
| <20 | 2 (1.53) | 12 (1.98) | |
| ≥20 | 129 (98.47) | 595 (98.02) | |
| TNM stage | 0.094 | ||
| Ⅰ | 14 (10.69) | 99 (16.31) | |
| Ⅱ | 69 (52.67) | 259 (42.67) | |
| Ⅲ | 40 (30.53) | 222 (36.57) | |
| Ⅳ | 8 (6.11) | 27 (4.45) | |
Note: *Statistical significance.
Abbreviations: MMR, mismatch repair; dMMR, deficient MMR; pMMR, proficient MMR; CRC, colorectal cancer; TNM, tumor, node, metastasis.