Table 4.
Association of MSI Status with Clinicopathological Characteristics from CRC Patients
| Characteristics | MSI status, n (%) | p-value | |
|---|---|---|---|
| MSI-H, n=74 | MSI-L/MSS,n=664 | ||
| Age, years | <0.001* | ||
| <50 | 27 (36.49) | 99 (14.91) | |
| ≥50 | 47 (63.51) | 565 (85.09) | |
| Sex | 0.455 | ||
| Male | 40 (54.05) | 393 (59.19) | |
| Female | 34 (45.95) | 271 (40.81) | |
| Tumor location | <0.001* | ||
| Left-sided colon | 23 (31.08) | 151 (22.74) | |
| right-sided colon | 42 (56.76) | 141 (21.23) | |
| Rectal | 9 (12.16) | 372 (56.02) | |
| Differentiated degree | <0.001* | ||
| Well or moderate | 41 (55.41) | 537 (80.87) | |
| Poor | 33 (44.59) | 127 (19.13) | |
| Distant metastasis | 0.243 | ||
| No | 73 (98.65) | 630 (94.88) | |
| Yes | 1 (1.35) | 34 (5.12) | |
| Histology type | 0.037* | ||
| Non-mucinous | 52(70.27) | 535(80.57) | |
| Mucinous | 22(29.73) | 129(19.43) | |
| Ki-67 (%) | 0.207 | ||
| <20 | 0 (/) | 14 (2.11) | |
| ≥20 | 74 (100) | 650 (97.89) | |
| TNM stage | <0.001* | ||
| Ⅰ | 3 (4.05) | 110 (16.57) | |
| Ⅱ | 49 (66.22) | 279 (42.02) | |
| Ⅲ | 21 (28.38) | 241 (36.30) | |
| Ⅳ | 1 (1.35) | 34 (5.12) | |
Note: *Statistical significance.
Abbreviations: MSI, microsatellite instability; MSI-H, high microsatellite instability; MSI-L/MSS, low microsatellite instability or microsatellite stable; CRC, colorectal cancer; TNM, tumor, node, metastasis.