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. 2020 Apr 24;13:3511–3523. doi: 10.2147/OTT.S238714

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© 2020 Liu et al.

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The proliferation, migration and invasion capacities of A549 cells were markedly decreased when MFN1 expression was blocked by siRNA. (A and B) High glucose increased the cell viability and BrdU incorporation of cells in a MFN1-dependent manner. (C and D) Effects of high glucose on A549 cell migration were measured by scratch wound assay (C) and Transwell assay (D). (E) SiMFN1 inhibited the high glucose-induced invasion of A549 cells. Data shown are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs NG+NC group. ^#P < 0.05, ^##P < 0.01 vs HG+NC group (n = 6).

Abbreviations: NC, non-targeted control; NG, normal glucose; HG, high glucose. MFN1, mitofusin1; siMFN1, small interfering RNA of MFN1.