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. 2020 Apr 24;13:3511–3523. doi: 10.2147/OTT.S238714

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© 2020 Liu et al.

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CLQ partially inhibited the progression of EMT induced by high glucose. (A and B) CLQ administration prevented high glucose-induced expression of EMT markers in A549 cells. (C and D) Immunofluorescence staining of N-cadherin and E-cadherin after CLQ treatment in high glucose conditions. (E) Boyden chamber assay results for the A549 cell line. (F) Effect of the autophagy inhibitor CLQ on A549 cell invasion. (G) The expression of MFN1 was determined after CLQ treatment. Scale bars = 100 µm. Data shown are mean ± SEM. *P < 0.05, **P < 0.01 vs NG group. ^#P < 0.05, ^##P < 0.01 vs HG group (n = 4).

Abbreviations: CLQ, chloroquine; EMT, epithelial-to-mesenchymal transition; NG, normal glucose; HG, high glucose. MFN1, mitofusin1; DAPI, 4ʹ,6-diamidino-2-phenylindole.