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. 2019 Nov 1;161(1):bqz013. doi: 10.1210/endocr/bqz013

Figure 3.

Figure 3.

Hepatic LEPR alters liver triglyceride homeostasis. (a) Body composition, (b) glucose (6-hour fast, 2 g/kg glucose), and (c) insulin (5-hour fast, 0.5 U/kg insulin) tolerance tests, and (c, inset) kg30 in 8- to 10-week-old male mice (n = 6). (d) Liver triglycerides in chow-fed male 8- to 10-week-old mice (n = 3-4) and (e) 24- to 32-week-old mice following 4 days of vehicle or glucagon receptor agonism (10 nmol/kg/d IUB288) (n = 11-15). (f) Oral lipid tolerance test and (g) area under the curve with IUB288. Pretreatment of IUB288 at t = -60 and corn oil oral gavage t = 0 (n = 8-9). (h) Liver triglycerides with 4-day dose response (6 nmol and 8 nmol/kg/d) IUB288 in chow-fed 21- to 28-week-old male mice (n = 5-6). Data are represented as mean ± SEM. *P < 0.05, **P < 0.01, ****P < 0.0001 compared with respective genotypic control. #P < 0.05 compared with control vehicle animals. ND, no data.