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. 2020 Apr 25;26(6):797–808. doi: 10.1093/ibd/izaa085

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© 2020 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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FIGURE 4. — ACE2 and TMPRSS2 expression in CD11b-enriched cell isolates from biopsies of patients with IBD. Cells isolated from mucosal biopsies were analyzed via RNA sequencing and expression of SARS-CoV-2 entry genes was determined. Expression levels shown were analyzed using mixed-effects models to properly account for correlations within patients; these models correct the effect of multiple samples collected from the same patient. A, Differential expression of genes in ileum (n = 26) and colon (n = 33) samples from n = 31 patients; ***P < 0.001. B, Differential expression of genes in CD (n = 22) and UC (n = 37) samples from n = 31 patients. C, Differential expression of genes in different segments of the gut segregated by inflamed and noninflamed pathology. D, TPM of selected genes expressed in CD11b-enriched cell isolates and segregated by gut location; n = 26 (ileum) and n = 33 (colon) samples.