Table 4:
Examples of human selenoproteins involved in the regulation of brain physiology that can be inhibited by E+Hg. The Hg effects were based on animal or in vitro models. The proteins that affected rodents or in cultured cells were selected and then the human protein information was obtained at www.uniprot.org.
| Protein | Gene | CXXC | CXC | CC | C | CXXU | CXU | CU | U | aa | Function | Localization | Hg effects | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Glutathione peroxidase 1 | GPX1 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 1 | 203 | Oxidoreductase | Cytoplasm | Inhibition | Franco et al. 2009 |
| Glutathione peroxidase 4 | GPX4 | 0 | 0 | 0 | 9 | 0 | 0 | 0 | 1 | 197 | Peroxidase | Mitochondrion | Inhibition | Zemolin et al. 2012 |
| Iodothyronine deiodinase Type I | DIO1 | 0 | 0 | 0 | 4 | 0 | 1 | 0 | 1 | 249 | Thyroid hormone synthesis | Endoplasmic reticulum | Inhibition | Pantaleão et al. 2017 |
| Iodothyronine deiodinase Type II | DIO2 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 2 | 273 | Thyroid hormone biosynthesis, | Plasma Membrane | Inhibition | Mori et al. 2006 |
| Selenoprotein P | SELENOP | 1 | 1 | 1 | 17 | 1 | 4 | 1 | 10 | 381 | Transport of selenium | Extracellular region | Inhibition | Sasakura et al. 1998 |
| Selenoprotein W | SELENOW | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 1 | 87 | Antioxidant, redox-related process | Cytoplasm | Down-regulation | Kim et al. 2005 |
| Thioredoxin reductase 1 | TXNRD1 | 1 | 0 | 0 | 17 | 0 | 0 | 1 | 1 | 649 | Oxidoreductase | Cytoplasm | Inhibition | Carvalho et al. 2008 |