Table 5. Prevalence of selected triggers and ADEs.
| No. | Selected Triggers, n | Total ADEs | Preventable ADEs | |||
|---|---|---|---|---|---|---|
| n | PPV, % | n | PPV, % | |||
| Laboratory index | ||||||
| 1 | PTT > 100s | 2 | 2 | 100.00% | 1 | 50% |
| 2 | INR > 5 | 2 | 2 | 100.00% | 1 | 50% |
| 3 | Glucose < 2.8mmol/L | 6 | 4 | 66.67% | 2 | 33.33% |
| 4 | Rising BUN or serum creatinine greater than 2 times baseline | 10 | 2 | 20.00% | 1 | 10% |
| 5 | ALT (or AST) ≥3 ULN and / or ALP≥2 ULN and T-BIL > 2UNL (can have abnormal INR) | 51 | 31 | 60.78% | 0 | 0.00% |
| 6 | PLT < 75×109/L | 39 | 13 | 33.33% | 0 | 0.00% |
| 7 | WBC < 3.0×109/L | 52 | 37 | 71.15% | 0 | 0.00% |
| 8 | Decrease of greater than 25% in hemoglobin or hematocrit | 9 | 4 | 44.44% | 2 | 22.22% |
| 9 | K+ < 3.5mmol/L | 109 | 6 | 5.50% | 2 | 1.83% |
| 10 | K+ > 5.5mmol/L | 13 | 3 | 23.08% | 3 | 100.00% |
| Antidote | ||||||
| 11 | Antiallergic | 70 | 16 | 22.86% | 1 | 1.43% |
| 12 | Anti-emetic | 536 | 101 | 18.84% | 0 | |
| 13 | Antidiarrheal | 31 | 16 | 51.61% | 7 | 22.58% |
| 14 | Laxative | 137 | 14 | 10.22% | 1 | 0.73% |
| 15 | Transfusion or use of blood products | 28 | 5 | 17.86% | 2 | 7.14% |
| Clinical symptom | ||||||
| 16 | Over sedation/hypotension | 18 | 10 | 55.56% | 1 | 5.56% |
| 17 | Rash | 19 | 14 | 73.68% | 0 | 0.00% |
| 18 | Heart rates <60/min | 3 | 2 | 66.67% | 0 | 0.00% |
| Intervention | ||||||
| 19 | Abrupt medication stops | 40 | 40 | 100.00% | 4 | 10.00% |
| Other | ||||||
| 20 | Others ADEs (ADEs not related to one of the triggers listed above) | 18 | 18 | 100.00% | 2 | 11.11% |
| Subtotal | 1193 | 340 | 28.50% | 30 | 2.51% | |
PTT, partial thromboplastin time; INR, international normalized ratio; BUN, blood urea nitrogen, ALT, alanine aminotransferase; AST, aspartate aminotransferase; T-BIL, total bilirubin; PLT, platelets; WBC, white blood cells; K+, potassium; UNL, upper limit of normal; PPV, positive predictive value.