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. 2020 Apr 28;15(4):e0232095. doi: 10.1371/journal.pone.0232095

Table 6. Prevalence of excluded triggers and ADEs.

No. Not-selected Triggers, n Total ADEs Preventable ADEs
n PPV, % n PPV, %
Laboratory index
1 HGB > 170g/L(man), > 150g/L(woman) 0 0 0
2 Ca2+ > 2.62 mmol/L 4 0 0.00% 0 0.00%
3 TSH < 0.27 mU/L or FT4 > 22.40 pmol/L 1 0 0.00% 0 0.00%
4 TSH > 4.2mU/L or FT4 < 12.0 pmol/L 13 0 0.00% 0 0.00%
5 Clostridium difficile positive 0 0 0
Plasma concentration
6 Digoxin > 2 ng/ mL 0 0 0
7 Gentamicin or Tobramycin levels peak > 10mg/L, trough > 2mg/L 0 0 0
8 Cyclosporin > 300μg/mL 0 0 0
9 Theophylline > 20mg/L 0 0 0
10 Tacrolimus > 20 ng/mL 0 0 0
11 Voriconazole levels > 5.5mg/L 0 0 0
Antidotes
12 Vitamin K 29 1 3.45% 1 3.45%
13 Romazicon (Flumazenil) 117 0 0.00% 0 0.00%
14 Naloxone (Narcan) 4 0 0.00% 0 0.00%
15 50% glucose 0 0 0
16 Protamine 6 0 0.00% 0 0.00%
17 Epinephrine 230 2 0.87% 0 0.00%
18 Glucose injection and regular insulin 30 0 0.00% 0 0.00%
19 Insulin (regular insulin or insulin analogue) used in non-diabetics 2 0 0.00% 0 0.00%
Clinical symptoms
20 Dehydration 1 0 0.00% 0 0.00%
21 Psychosis 1 0 0.00% 0 0.00%
22 Respiratory rates < 12 /min 15 0 0.00% 0 0.00%
Subtotal 426 3 0.70% 1 0.23%

HGB, hemoglobin; Ca2+, calcium; TSH, thyroid stimulating hormone; FT4, free thyroxine.