Table 3. Characteristics of studies which assessed the risk of future endometrial cancer in women with endometrial hyperplasia which did not report mean or median follow-up and for which rates per person-years calculations were not possible (n = 11).
| Author, Year Location | Study population | Study design | Recruitment period | No. EH cases | No EC cases | % progression | Age (mean) | Method of initial investigation | Method of follow-up investigation | Follow-up time | EH investigated | Quality score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Anastasiadis, 2000 Greece [44] | General Hospital of Alexandroupolis | Single-center retrospective cohort | 1986–1998 | 294 (258 NAH, 36 AH) | 4 (1 SH, 2 CH, 1 AH) | 1.4 | Not reported | D&C, hysteroscopy | D&C | At least 6 months | All | 4 |
| Chen, 2016 China [45] | Peking Union Medical College Hospital | Single-center retrospective cohort | 2000–2011 | 16 | 2 | 12.5 | 20–42 (range) | Biopsy, D&C, hysteroscopy | Hysterectomy | At least 3 months | CH | 5 |
| Hecht, 2005 Israel [46] | Beth Israel Hospital | Single-center retrospective cohort | 1998–2000 | 84 (21 CAH, 15 CH, 48 SH) | 8 (5 CAH, 2 CH, 1 SH) | 9.5 | Not reported | Biopsy, D&C | Hysterectomy, endometrial sampling or clinical follow-up | Not reported | All | 4 |
| Inversen, 2018 Denmark [47] | Regional Hospital Holstebro, Aarhus University Hospital | Two-center retrospective cohort | 2000–2005 | 114 | 17 | 14.9 | 59.1 | Biopsy, D&C, Trans cervical hysteroscopic endometrial resection | Hysterectomy | 9–14 years | CH | 5 |
| Lacey, 2008 USA [48] | Kaiser Permanente Northwest | Population-based nested case-control | 1970–2003 | 368 (127 cases and 241 controls) | 127 | Not applicable | 52 | Biopsy, D&C | Hysterectomy | 6.7 years (median, range 1–24.5) | All | 7 |
| Minig, 2011 Italy [49] | European Institute of Oncology, Milan | Single-center prospective cohort | 1996–2009 | 20 | 1 | 5 | Not reported | Pipelle biopsy, D&C, hysteroscopy | Hysterectomy | At least 6 months | AH | 5 |
| Orbo, 2000 Norway [50] | Northen Norway | Multicenter retrospective cohort | Not reported | 68 (9 SH, 10 CH, 13 SAH, 36 CAH) | 18 (1 CH, 1 SAH, 16 CAH) | 26 | 28–77 (range) | D&C | Hysterectomy | 10–20 yearsa | All | 5 |
| Simpson, 2014 Canada [51] | Princess Margaret Hospital and Odette Cancer Center | Two-center retrospective cohort | 2000–2011 | 19 | 6 | 31.6 | All <45 | Biopsy, D&C | Hysterectomy | 39 months (median, range 5–128)b | CAH | 5 |
| Tabata, 2001 Japan [52] | Yamada Red Cross Hospital | Single-center prospective cohort | 1989–1996 | 77 (48 SH, 17 CH, 1 SAH, 11 CAH) | 1 (CAH) | 1.3 | 47.2 (SH), 46.6 (CH), 52.0 (SAH), 47.9 (CAH) | D&C | D&C | At least 1 year | All | 4 |
| Ushijima, 2007 Japan [53] | Japan Gynecologic Cancer Study Group | Multicenter prospective trial | Not reported | 17 | 2 | 11.8 | 20–39 (range) | D&C | Hysterectomy | At least 8 weeks | AH | 5 |
| Wheeler, 2007 USA [54] | Johns Hopkins Hospital | Single-center retrospective cohort | Not reported | 18 | 2 | 11.1 | 34 (median, range 24–47)c 61 (median, range 50–77)d | Biopsy, D&C | Biopsy, hysterectomy | 3–25 months | CAH | 4 |
EH- endometrial hyperplasia, EC- endometrial cancer, AH- atypical hyperplasia, SH-simple hyperplasia, CAH- complex atypical hyperplasia, D&C- dilation and curettage, SAH- simple atypical hyperplasia, CH-complex hyperplasia, TVUS- transvaginal ultrasound scan, NAH- non-atypical hyperplasia
a Follow-up is among EH patients who developed endometrial cancer
b Follow-up time also includes grade 1 EC patients (n = 25)
c Premenopausal women
d Postmenopausal women