Table 4.

Antimicrobial and other bioactive peptides produced by the intein‐mediated systemThe peptides labelled with an asterisk (*) are antimicrobial peptides. Size is shown as the number of amino acid residues. Further abbreviations used: ABP‐CM4, antibacterial peptide CM4 (see Table 1); Bin‐1b, an antimicrobial‐like protein also known as sperm‐associated antigen 11 precursor; hBNP, human brain natriuretic peptide; hEGF, human epidermal growth factor; M65, a deletion mutant of Maxadilan, a vasodilator peptide isolated from sandfly salivary glands; rhPACAP, recombinant human pituitary adenylate cyclase‐activating polypeptide; rMBAY, a peptide designed to imitate BAY 55‐9837, a VPAC2 (vasoactive intestinal peptide receptor 2)‐selective agonist developed by Bayer Corporation; rMROM, a 32‐amino‐acid VPAC2 agonist; SMAP‐29, sheep myeloid antimicrobial peptide 29.

Peptide	Size	Fusion solubility	Yield (mg/litre)	Reference
ABP‐CM4*	35	Soluble	4.2	[60]
Aldolase A fragment	26	Soluble	1.4	[77]
β‐Defensin 1*	37	Partially soluble	4.5	[78]
β‐Defensin 2*	41	Partially soluble	4.1	[78]
Bin‐1b*	49	Partially soluble	3.2	[78]
Divercin V41*	43	Soluble	NAa	[79]
Enterocin P*	44	Soluble	NA	[79]
Glucagon	29	Partially soluble	11.9	[80]
hBNP	32	Insoluble	2.4	[81]
hEGF	53	Insoluble	17–18	[82]
Huwentoxin‐1	33	Soluble	7.8	[83]
Maxadilan	67	Soluble	5.0	[84]
M65	50	Soluble	5.3	[84]
Pediocin PA‐1*	44	Soluble	NA	[79]
Piscicolin 126*	44	Soluble	1.1	[79]
rhPACAP	39	Soluble	22	[85]
rMBAY	32	Soluble	53	[86]
rMROM	32	Soluble	6.8	[87]
SMAP‐29*	29	Soluble	0.1–0.2	[88]

^aNot available.