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. 2020 Mar 30;12(4):215–229. doi: 10.14740/jocmr4142

Table 5. Potential Therapeutic Options for COVID-19.

Drug Mechanism of action Dose and frequency Mode of administration
Vitamin A, B, C, D, E, thymosin alpha-1, thymopentin Antioxidants/enhance immunity Oral
Selenium, zinc and pyrithione combination Enhance immunity Oral
Interferon-β Inhibit the replication of SARS-CoV and MERS-CoV replication Sub-cutaneous
Interferon-α Inhibit the replication of SARS-CoV and MERS-CoV replication 5 million U twice a day for a maximum of 10 days Inhalation
Chloroquine Spike (S)-protein angiotensin-converting enzyme 2 (ACE-2) blockers 500 mg twice daily for a maximum of 10 days Oral
Mefloquine Unknown N/A Oral
Favipiravir RNA-dependent RNA polymerase (RdRp) inhibitor Proposed dose, 600 mg tid with 1,600 mg first loading dosage for a maximum of 14 days Oral
Remdesivir RdRp inhibitor 200 mg on day 1 followed by 100 mg daily for 9 days Intravenous
Darunavir Protease inhibitor 800 mg daily Oral
Lopinavir/ritonavir Protease inhibitor 200 mg/50 mg, two capsules twice a day for a maximum of 10 days Oral
Ribavirin Nucleoside analogue 500 mg, 2 to 3 times per day Intravenous infusion in combination with lopinavir/ritonavir + interferon-α
Arbidol 200 mg three times a day for a maximum of 10 days Oral
Type II transmembrane serine protease (TMSPSS2) inhibitors (Brand - Camostat) TMSPSS2 inhibitors Oral