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. 2019 Dec 10;15(5):524–535. doi: 10.1080/15592294.2019.1699894

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This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.

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Figure 2. — (a) Percentage change in DNA methylation associated with a 5 µg/m3 increase in ambient PM_2.5, results from linear regression. The X-axis refers to different genes; the Y-axis refers to the corresponding changes (mean and 95% confidence interval). (b) Percentage change in DNA methylation associated with a 5 µg/m³ increase in ambient PM_2.5 at each decile of the methylation. The X-axis refers to different quantiles; the Y-axis refers to the corresponding changes (mean and 95% confidence interval). (Number of subjects in LINE-1 analyses is 491; number of subjects in locus-specific analysis is 882).

LINE-1: long interspersed nucleotide element; TNF-α: tumour necrosis factor-alpha; TLR-2: toll-like receptor-2; PM_2.5: particulate matter with aerodynamic diameter less than or equal to 2.5 µm.