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. 2019 Dec 18;15(5):483–498. doi: 10.1080/15592294.2019.1695341

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — DNA methylation dynamics in medaka PGCs. (a): Global CpG methylation levels observed in PGCs at different stages of life history; (b): Beanplots showing the distribution of CpG methylation levels of the pooled replicates of medaka blastula and PGCs. Methylation was quantitated by taking 5 kb genomic probes approach; (c): Distribution of CpG methylation levels across the genome; (d): Average CpG methylation of the genomic features in PGCs at different stages of life history; (e): Average CpG methylation profiles over all medaka annotated genes starting from 5 kb upstream (−5 kb) of the transcription start site (TSS), through scaled gene bodies to 5 kb downstream (+5 kb) of transcription end sites (TESs); (f): Average CpG methylation profiles over all medaka CpG islands, CGI shores, and CGI shelves.