Figure 4.

Differentially methylated promoters (DMP) identified during PGC reprogramming. (a): Differentially methylated promoters in PGCs at different stages of life history; (b): DMPs that were hypermethylated in 25-dpf male PGCs were still at the hypomethylated state in female PGCs at the 25-dpf stage indicating de novo methylation taking place in male PGCs earlier than in females; (c): Gene ontology enrichment of DMPs hypomethylated in 12-dpf compared with 10-dpf PGCs; (d): Gene ontology and pathway enrichment of DMPs hypomethylated in 25-dpf male compared with 15-dpf PGCs.