. 2020 Apr 21;13:59. doi: 10.3389/fnmol.2020.00059

TABLE 5.

Summary of LAMA2-CMD mice lacking other genes.

Approach	Deletion	Mouse model	Muscle condition and overall health	References
Extracellular matrix and receptor modulation	Integrin α7	dy^3K/dy^3K	No difference	Gawlik and Durbeej, 2015
	Dystrophin	dy^3K/dy^3K	Worsened	Gawlik et al., 2014
	β-sarcoglycan	dy^3K/dy^3K	Worsened	Gawlik et al., 2014
	Laminin α4	dy^3K/dy^3K	Overall phenotype worsened but skeletal muscle condition remains to be reported	Miner et al., 2004
		dy^2J/dy^2J
Apoptosis inhibition	Bax	dy^W/dy^W	Improved	Girgenrath et al., 2004
Modulation mitochondrial permeability transition	Cyclophilin D	dy^W/dy^W	Improved	Millay et al., 2008
Inflammation and fibrosis modulation	Complement C3	dy/dy	Improved	Connolly et al., 2002
	Galectin-3	dy^3K/dy^3K	No difference	Gawlik et al., 2017
	Osteopontin	dy^3K/dy^3K	Slightly worsened	Gawlik et al., 2017
	miR-21	dy^3K/dy^3K	No difference	Moreira Soares Oliveira et al., 2017
		dy^2J/dy^2J	No difference
Muscle growth	Myostatin	dy^W/dy^W	No difference	Li et al., 2005