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muIL-36 R targeted mAbs bind with high affinity. Solution phase equilibrium binding measurements of rat anti-muIL-36 R and chimeric mouse/rat anti-muIL-36 R surrogate mAbs to recombinant muIL-36 R (titrant) show that M616 binds mu rIL-36 R 3.3-fold tighter than the chimeric chM616. Note: these values represent the intrinsic binding affinity to IL-36 R target in solution in the absence of avidity.
