Figure 2.

Characterization of dose-dependent single-dose serum PK of rat anti-muIL-36 R (M616) in female C57BL/6 mice. Main: Log-linear mean (n = 3/time point) serum concentration profile observed after 0.04, 0.4, and 4 mg/kg IV doses. Note the several distinct phases of non-linear behavior captured at 4 mg/kg by the extended duration of blood sampling. Inset: Three separate routes of administration (IP, IV, and SC) at 4 mg/kg dose are shown for comparison. Bioavailability >80% was observed by both IP and SC dosing routes, suggesting minimal catabolism at the site of injection.