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. 2020 Apr 20;12(1):1746520. doi: 10.1080/19420862.2020.1746520

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Tissue pharmacokinetics of ¹²⁵I-M616 (left) and ¹¹¹In-M616 (right) after administration of 0.3 mg/kg IV dose in male C57BL/6 mice (n = 3/time point). Quantitation of ¹²⁵I-M616 PK in tissues suggests kidney, lung, and heart are the primary sites of tissue exposure in C57BL/6 mouse. A complementary analysis using ¹¹¹In-M616 confirms the role of the kidney as a site of elevated M616 catabolism based on probe residualization in this organ. Note: both absolute levels (%ID/g) and a shift in t_max for ¹¹¹In-M616 in kidney relative to other tissues indicates specific catabolism.