Table 2.

Summary of the parameter estimates generated by fitting anti-muIL-36 R (M616) serum concentration-time data (0.04, 0.4 and 4 mg/kg, IV) in TMDD model.

Parameter name (unit)	Parameter estimate	CV%	Source
k12 (h−1)	0.0880	11.1	Estimated
kel (h−1)	0.01	9.02	Estimated
kint (h−1)	5.15	10.1	Estimated
kdeg (h−1)	1.27	7.86	Estimated
V (L)	0.000944	-	Fixeda
Ro (M)	7.94e-10	-	Fixedb
koff(h−1)	0.00127	-	Fixedc
KD (M)	6.3e-12	-	Fixedd

^aPhysiological mouse plasma volume was used (see Shah & Betts, J Pharmacokinet Pharmacodyn, 2012).

^bRo was taken from Ahlberg et al., mAbs, 2019.

^ck_off was fixed to average mAb value.

^dK_D was experimentally determined.