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Biodistribution study design incorporating both non-residualizing (125I) and residualizing (111In) radio-tracers for M616 for quantitation.
| Group (n = 24) | Total M616 Dose (mg/kg) | Tracer (% of M616 Material Labeled) | Route# | Tissues Sampled |
|---|---|---|---|---|
| 1 | 0.3 | 125I (100) | IV | Whole-blood, heart, liver, lung, kidney, spleen, thymus, brain, skin (middle between shoulders), muscle, femur, lymph nodes |
| 2 | 10 | 125I (3) | IV | |
| 3 | 0.3 | 111In (100) | IV | |
| 4 | 10 | 111In (3) | IV |
# Time Points: 0.5, 2, 4, 12, 24, 48, 96, 120 h.
