Table 2.
Inhibition of RANTES/CCL5-induced human donor monocyte chemotaxis.
| Human Blood Donor | Inhibition of Chemotaxis (IC50) | Max. % Inhibition |
|---|---|---|
| 1 | 371 pM | 79.98 |
| 2 | 636 pM | 50.6 |
| 3 | 852 pM | 87.83 |
| 4 | 1.22 nM | 87.29 |
| 5 | 2.02 nM | 90.45 |
| 6 | 4.36 nM | 92.9 |
| 7 | 7.17 nM | 90.4 |
| 8 | 16.7 nM | 95.53 |
CD14+ monocytes were isolated from human PBMCs using MACS® technology, and chemotaxis of monocytes toward RANTES/CCL5 was assessed in a transwell assay format. All data for mAb 14Y029-133D02 with monocytes harvested from 8 independent human blood donors is shown.