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. 2020 Apr 29;2(4):e0098. doi: 10.1097/CCE.0000000000000098

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Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 3. — Depiction of an adaptive trial design. Width of green arrows corresponds to number of patients allocated to each trial intervention. A, Demonstrates an adaptive trial design addressing five different treatment interventions. B, Demonstrates 10 traditional randomized controlled trials (RCTs) that would be necessary to address the same five treatment interventions.