Key Resources Table
| REAGENT or RESOURCE | SOURCE | IDENTIFIER |
|---|---|---|
| Antibodies | ||
| Mouse anti-GFAP | Abcam | ab8049 |
| Guinea anti-vGlut1 | Millipore | AB5905 |
| Goat anti-CTB | List biological laboratories | 703B |
| Mouse anti-synaptophysin | Abcam | ab8049 |
| Rabbit anti-tyrosine hydroxylase | Abcam | ab112 |
| Rabbit anti-serotonin | Sigma-Aldrich | S5545 |
| Goat anti-serotonin | Abcam | ab66047 |
| Rabbit anti-TOM20 | Santa Cruz | sc-11415 |
| Rabbit anti-laminin | Abcam | ab11575 |
| Rabbit anti-fibronectin | Abcam | ab2413 |
| Rabbit anti-collagen I | Abcam | ab34710 |
| Donkey anti-mouse (Alexa Fluor® 405) | Abcam | ab175658 |
| Goat anti-guinea pig (Alexa Fluor® 647) | Thermo Fisher Scientific | A-21450 |
| Donkey anti-rabbit (Alexa Fluor® 488) | Thermo Fisher Scientific | A-21206 |
| Donkey anti-rabbit (Alexa Fluor®594) | Thermo Fisher Scientific | R37119 |
| Donkey anti-goat (Alexa Fluor®594) | Thermo Fisher Scientific | A-11055 |
| Bacterial and Virus Strains | ||
| AAV2-GFP | Dr. George Smith | Temple University |
| AAV9-mito-GFP | Dr. George Smith | Temple University |
| HiRet-tre-hM4Di-mCherry | Dr. George Smith | Temple University |
| AAV2-CMV-rtTAV16 | Dr. George Smith | Temple University |
| Chemicals, Peptides, and Recombinant Proteins | ||
| Grx-1-roGFP2 | Dr. Chang Chen | Chinese Academy of Science |
| Cholera Toxin B Subunit (Choleragenoid) from Vibrio cholerae (CTB) | List biological laboratories | 103B |
| CMTMros mitotracker | Thermo Fisher Scientific | M7510 |
| Antimycotic | Thermo Fisher Scientific | 15240062 |
| Dextran, biotin, 10000MW, lysine fixable (BDA-10000) | Invitrogen | D1956 |
| Clozapine-n-oxide (CNO) | Sigma-Aldrich | C0832-5MG |
| Doxycycline (Dox) | Sigma-Aldrich | D1822-500MG |
| Paraformaldehyde | Sigma-Aldrich | P6148-5KG |
| Creatine monohydrate | Sigma-Aldrich | C3630-100G |
| DAPI | Sigma-Aldrich | D9542-1MG |
| ExtrAvidin® TRITC | Sigma-Aldrich | E3011-1ML |
| ExtrAvidin® FITC | Sigma-Aldrich | E2761-1ML |
| Critical Commercial Assays | ||
| Creatine Kinase Activity Assay Kit | Abcam | ab155901 |
| TSA Biotin Tyramide Reagent Pack | PerkinElmer | SAT700001EA |
| Vectastain R.T.U. Elite ABC Reagent | Vector Laboratories | PK-7100 |
| Experimental Models: Organisms/Strains | ||
| C57BL/6J mice | The Jackson Laboratory | Stock No: 000664 |
| snph+/+ adult mice | (Kang et al., 2008) | N/A |
| snph−/− adult mice | (Kang et al., 2008) | N/A |
| REAGENT or RESOURCE | ||
| Mouse WT and snph KO forward primer GGAAGCCCCGAACCACGTGCC |
(Kang et al., 2008) | N/A |
| Mouse WT reverse primer ATCCGGCAGAGGCTCGTCTAC |
(Kang et al., 2008) | N/A |
| Mouse snph KO reverse primer ACGAGACTAGTGAGACGTGCT |
(Kang et al., 2008) | N/A |
| Software and Algorithms | ||
| Adobe Illustrator CC 2018 | Adobe Systems | https://www.adobe.com/products/illustrator.html |
| Adobe Photoshop CC 2018 | Adobe Systems | https://www.adobe.com/products/photoshop.html |
| Fiji | Schindelin et al., 2012 | http://fiji.sc/ |
| GraphPad Prism version 7.0 | GraphPad Software, Inc | https://www.graphpad.com/scientific-software/prism/ |
| Image-Pro Plus 6.0 | Media Cybernetics | http://www.mediacy.com/imageproplus |
| Imaris | Bitplane | http://www.bitplane.com/ |
| Matlab | Mathworks | https://www.mathworks.com/products/matlab.html |
| RStudio | N/A | www.r-project.org |