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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Arthritis Rheumatol. 2020 Mar 30;72(5):780–790. doi: 10.1002/art.41188

Figure 3. TNIP1 SLE risk alleles differentially affect nuclear complex binding in immune cells.

Figure 3.

EMSAs were performed using biotinylated oligonucleotides containing the non-risk or risk alleles of the indicated variants. Nuclear extracts were from Jurkat (A,B), THP-1 (C,D), or EBV B (E,F) cells at rest (A,C,E) or after P/I stimulation (B,D,F). Statistical comparisons were performed using paired t-test; * indicates p<0.05; ** indicates p<0.01. Circles indicate non-risk allele; Squares indicate risk allele. Representative images are in Supplementary Figures 2–4.