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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Biol Psychiatry. 2019 Oct 29;87(11):1001–1011. doi: 10.1016/j.biopsych.2019.10.012

Figure 6.

Figure 6.

Schematic illustration of the novel multi-order hippocampus-hypothalamic-hindbrain circuit. (1) GHSR1a is expressed in vCA1 glutamatergic projection neurons (red) in the pyramidal layer, which communicate monosynaptically to (2) dpLHA orexin neurons (blue) that project to (3) LDTg ORX-1R in the hindbrain (green). This pathway is critical for promoting meal size through interactions between vCA1 HPC ghrelin and downstream LHA orexin signaling to the LDTg. GHSR1a: type 1a growth hormone secretagogue receptor; dpLHA: dorsal perifornical region of the lateral hypothalamic area; LDTg: laterodorsal tegmental nucleus; ORX-1R: orexin-1 receptor.