Table 4.
Association of serum phosphorus with measures of LV structure and function: The ARIC Study, 2011–2013
| Visit 5 | Phosphorus Quintiles | P for trend | ||||
|---|---|---|---|---|---|---|
| 1.8–3.0 mg/dL | 3.1–3.3 mg/dL | 3.4–3.5 mg/dL | 3.6–3.8 mg/dL | 3.9–6.2 mg/dL | ||
| N | 911 | 1178 | 910 | 1222 | 992 | |
| LV structure | ||||||
| End Diastolic Diameter (cm) | 4.41 (4.37,4.45) | 4.40 (4.37,4.44) | 4.40 (4.36,4.44) | 4.37 (4.34,4.41) | 4.39 (4.35,4.43) | 0.16 |
| End Diastolic Volume Index (mL /m2) | 43.4 (42.6,44.3) | 43.2 (42.5,44.0) | 43.4 (42.6,44.3) | 43.7 (42.9,44.4) | 43.9 (43.1,44.7) | 0.17 |
| LV Mean wall thickness (cm) | 1.01 (0.99,1.02) | 1.00 (0.99,1.01) | 0.99 (0.98,1.00) | 1.00 (0.99,1.01) | 1.01 (1.00,1.02) | 0.33 |
| LV mass index (g/m2) | 80.9 (79.2,82.6) | 79.8 (78.3,81.3) | 79.3 (77.6,80.9) | 79.7 (78.2,81.2) | 81.3 (79.7,83.0) | 0.63 |
| LV hypertrophy, (%) | 9.14 (6.40,11.9) | 8.87 (6.36,11.4) | 8.36 (5.67,11.1) | 9.90 (7.41,12.4) | 11.7 (9.00,14.3) | 0.06 |
| LV mass/end-diastolic volume | 1.88 (1.84,1.93) | 1.87 (1.83,1.91) | 1.85 (1.80,1.89) | 1.85 (1.80,1.89) | 1.88 (1.83,1.92) | 0.55 |
| Relative wall thickness | 0.43 (0.43,0.44) | 0.43 (0.42,0.44) | 0.43 (0.42,0.44) | 0.43 (0.43,0.44) | 0.44 (0.43,0.44) | 0.12 |
| LV systolic function | ||||||
| Ejection Fraction (%) | 66.0 (65.4,66.5) | 65.8 (65.3,66.4) | 66.0 (65.5,66.6) | 65.7 (65.2,66.2) | 65.7 (65.2,66.3) | 0.37 |
| Longitudinal strain (%) | −17.9 (−18.1,−17.7) | −17.9 (−18.1,−17.7) | −17.8 (−18.1,−17.6) | −17.8 (−18.0,−17.6) | −17.8 (−18.0,−17.6) | 0.30 |
| LV diastolic function | ||||||
| TDI septal e’ (cm/sec) | 5.81 (5.67,5.95) | 5.74 (5.61,5.87) | 5.80 (5.66,5.94) | 5.69 (5.57,5.82) | 5.68 (5.55,5.82) | 0.08 |
| Septal E/e’ ratio | 11.9 (11.5,12.3) | 12.2 (11.9,12.6) | 12.3 (12.0,12.7) | 12.3 (12.0,12.6) | 12.4 (12.1,12.8) | 0.02 |
| Left atrial volume index (mL/m2)* | 24.8(24.0,25.6) | 25.4(24.6,26.1) | 25.1(24.4,25.9) | 25.7(25.0,26.4) | 25.7(24.9,26.4) | 0.03 |
| eGFR: >90 mL/min per 1.73 m2 | 24.8 (22.7,27.0) | 25.1 (23.3,27.0) | 25.1 (22.9,27.4) | 26.1 (24.3,27.9) | 24.0 (22.0,26.1) | 0.92 |
| eGFR: 60-<90 mL/min per 1.73 m2 | 24.7 (23.7,25.7) | 25.1 (24.2,26.0) | 25.1 (24.2,26.1) | 24.7 (23.8,25.6) | 25.4 (24.4,26.3) | 0.51 |
| eGFR: <60 mL/min per 1.73 m2 | 23.8 (22.3,25.4) | 24.9 (23.4,26.3) | 24.0 (22.5,25.5) | 26.8 (25.4,28.1) | 25.8 (24.4,27.3) | 0.001 |
All values are shown as Mean (95% Confidence Interval) adjusted for age, sex, race-center, BMI, eGFR, heart rate, systolic blood pressure, sport index, cigarette smoking status, drinking status, diabetes, HDL-C, LDL-C, use of lipid lowering medications, use of antihypertensives, prevalent CHD at Visit
*
Since we observed significant interaction by eGFR in the association of serum phosphorus and LAVI (p-value: 0.002), analyses of LAVI was stratified across the eGFR categories.