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. 2020 Mar 28;85(5):831–842. doi: 10.1007/s00280-020-04054-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Mean (SD) cycle 1 plasma/serum concentration time profiles of pola by study phase and treatment in patients receiving pola 1.0–1.8 mg/kg in combination with R-CHP, or pola 1.4–1.8 mg/kg in combination with G-CHP. Dose-escalation arms are provided in a, c, with dose expansion arms in b, d. Pola analytes include acMMAE (a, b) and unconjugated MMAE (c, d). acMMAE antibody-conjugated MMAE, conc concentration, G-CHP obinutuzumab, cyclophosphamide, doxorubicin, and prednisone, MMAE monomethyl auristatin E, pola polatuzumab vedotin, R-CHP rituximab, cyclophosphamide, doxorubicin, and prednisone, SD standard deviation