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. 2019 Aug 31;22(6):870–877. doi: 10.1007/s12094-019-02197-6

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Trend for reduced overall survival in circulating tumour cell (CTC)-positive metastatic breast cancer patients. CTC number in 7.5 ml peripheral whole blood samples enumerated by the CellSearch technology was enumerated in metastatic breast cancer (MBC) patients. Log-rank (Mantel–Cox) testing compared survival in days from study entry in CTC-positive compared to CTC-negative patients. CTC positive defined as ≥ 1/7.5 ml. Assumption of proportionality was verified based on Schoenfeld residuals; n number of MBC patients in each group, CTC circulating tumour cell