Fig. 3.

Coagulation plasma markers TAT and d-dimer are associated with poorer survival in metastatic breast cancer. Coagulation markers thrombin–antithrombin III complex (TAT) and d-dimer were quantified by immunoassay in metastatic breast cancer (MBC) patient plasma samples. a TAT, cd-dimer: unpaired two-tailed t tests of Log₂ transformed raw coagulation marker concentrations compared to survival groups, **p < 0.01. Error bars show standard error of the mean (SEM). b TAT, dd-dimer: log-rank (Mantel–Cox) tests comparing survival in days from study entry in these coagulation markers dichotomised around the median values (TAT 5.9 mg/ml, d-dimer 895 ng/ml) were carried out, **p < 0.01. Assumption of proportionality was verified based on Schoenfeld residuals; n number of MBC patients in each group, TAT thrombin–antithrombin III complex