Table 3.

Mean percentage decrease in hip and spine bone mineral density with TDF and TAF in studies comparing the two drugs

Study	Follow-up		TAF	TDF	p
Buti, 2016 [29]	48 weeks	hip	− 0.29%	− 2.16%	< 0.0001
		spine	− 0.88%	− 2.51%	0.0004
Chan, 2016 [30]	48 weeks	hip	− 0.1%	− 1.72%	< 0.0001
		spine	− 0.42%	− 2.29%	< 0.0001