Table 3.
Association between four significant SNPs and GDM susceptibility.
| Genotype |
GDM cases (n = 964) N (%) |
Controls (n = 1,021) N (%) | OR (95%CI) | P | OR (95%CI)a | Pa |
|---|---|---|---|---|---|---|
| FTO rs1121980 | ||||||
| G/G | 688 (72.0) | 673 (66.5) | 1.00 | 1.00 | ||
| A/G | 243 (25.4) | 298 (29.4) | 0.80 (0.65–0.97) | 0.027 | 0.80 (0.65–0.98) | 0.028 |
| A/A | 25 (2.6) | 41 (4.1) | 0.60 (0.36–0.99) | 0.046 | 0.62 (0.37–1.04) | 0.071 |
| Dominant | 0.77 (0.64–0.94) | 0.009 | 0.78 (0.64–0.94) | 0.011 | ||
| Recessive | 0.64 (0.38–1.05) | 0.075 | 0.66 (0.40–1.11) | 0.112 | ||
| Additive | 0.79 (0.67–0.93) | 0.005 | 0.79 (0.67–0.94) | 0.007 | ||
| KCNQ1 rs163182 | ||||||
| G/G | 427 (45.4) | 398 (39.6) | 1.00 | 1.00 | ||
| C/G | 398 (42.3) | 462 (46.0) | 0.80 (0.66–0.97) | 0.025 | 0.80 (0.66–0.98) | 0.028 |
| C/C | 115 (12.2) | 144 (14.3) | 0.74 (0.56–0.99) | 0.039 | 0.73 (0.55–0.97) | 0.030 |
| Dominant | 0.79 (0.66–0.94) | 0.010 | 0.79 (0.65–0.94) | 0.010 | ||
| Recessive | 0.83 (0.64–1.08) | 0.171 | 0.81 (0.62–1.06) | 0.132 | ||
| Additive | 0.85 (0.74–0.96) | 0.011 | 0.84 (0.73–0.96) | 0.009 | ||
| MC4R rs12970134 | ||||||
| G/G | 590 (62.4) | 679 (67.0) | 1.00 | 1.00 | ||
| A/G | 300 (31.7) | 300 (29.6) | 1.15 (0.95–1.40) | 0.157 | 1.13 (0.93–1.38) | 0.218 |
| A/A | 55 (5.8) | 35 (3.5) | 1.81 (1.17–2.80) | 0.008 | 1.99 (1.28–3.09) | 0.002 |
| Dominant | 1.22 (1.01–1.47) | 0.036 | 1.22 (1.01–1.47) | 0.040 | ||
| Recessive | 1.73 (1.12–2.67) | 0.012 | 1.91 (1.23–2.95) | 0.003 | ||
| Additive | 1.23 (1.06–1.44) | 0.008 | 1.25 (1.07–1.46) | 0.006 | ||
| PROX1 rs340841 | ||||||
| C/C | 249 (26.3) | 312 (31.1) | 1.00 | 1.00 | ||
| C/T | 472 (49.8) | 492 (49.1) | 1.20 (0.98–1.48) | 0.084 | 1.27 (1.02–1.57) | 0.030 |
| T/T | 226 (23.9) | 199 (19.8) | 1.42 (1.10–1.83) | 0.006 | 1.49 (1.15–1.92) | 0.003 |
| Dominant | 1.27 (1.04–1.54) | 0.019 | 1.33 (1.09–1.63) | 0.005 | ||
| Recessive | 1.27 (1.02–1.57) | 0.031 | 1.28 (1.03–1.59) | 0.028 | ||
| Additive | 1.19 (1.05–1.35) | 0.006 | 1.22 (1.07–1.39) | 0.002 |
a
Logistic regression analyses adjusted for age, pre-pregnancy BMI, parity, abnormal pregnancy history, and family history of diabetes. GDM, gestational diabetes mellitus; SNP, single nucleotide polymorphism.