Table 4.
Cumulative effects of the four risk alleles on GDM susceptibility.
| Variables |
GDM cases (n = 964) N (%) |
Controls (n = 1,021) N (%) | OR (95%CI) | P | OR (95%CI)a | Pa |
|---|---|---|---|---|---|---|
| Combined effects of FTO rs1121980-G, KCNQ1 rs163182-G, MC4R rs12970134-A, and PROX1 rs340841-T | ||||||
| 0–3 | 205 (22.5) | 293 (29.8) | 1.00 | 1.00 | ||
| 4–5 | 540 (59.3) | 555 (56.5) | 1.39 (1.12–1.72) | 0.003 | 1.43 (1.15–1.78) | 0.001 |
| 6–8 | 165 (18.1) | 135 (13.7) | 1.75 (1.31–2.33) | <0.001 | 1.84 (1.37–2.47) | <0.001 |
| Trend | Pb < 0.001 | Pb < 0.001 | ||||
a
Logistic regression analyses adjusted for age, pre–pregnancy BMI, parity, abnormal pregnancy history, and family history of diabetes.
b
P-value of Cochran-Armitage's trend test. GDM, gestational diabetes mellitus.