Table 5.
Risk stratification for GDM using genetic risk score.
| Quartile | Risk score |
GDM cases (n = 964) N (%) |
Controls (n = 1,021) N (%) | OR (95%CI) | P | OR (95%CI)a | Pa |
|---|---|---|---|---|---|---|---|
| 0 | 0~ | 194 (21.3) | 283 (28.8) | 1.00 | 1.00 | ||
| 1 | 0.6555~ | 239 (26.3) | 259 (26.3) | 1.35 (1.05–1.74) | 0.022 | 1.39 (1.07–1.80) | 0.013 |
| 2 | 0.8227~ | 230 (25.3) | 247 (25.1) | 1.36 (1.05–1.76) | 0.019 | 1.41 (1.08–1.83) | 0.011 |
| 3 | 1.0101~ | 247 (27.1) | 194 (19.7) | 1.86 (1.43–2.41) | <0.001 | 1.94 (1.48–2.53) | <0.001 |
| Trend | Pb < 0.001 | Pb < 0.001 |
a
Logistic regression analyses adjusted for age, pre-pregnancy BMI, parity, abnormal pregnancy history, and family history of diabetes.
b
P-value of Cochran-Armitage's trend test. GDM, gestational diabetes mellitus.