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. 2020 Apr 28;10:7166. doi: 10.1038/s41598-020-64097-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CMR results (A) Representative CMR cine images in short axis (left) and four chamber views (right) of the different groups. (B) Evolution of LVEF through the study in CON (n = 7), MSPs (n = 7) and IGF-1 MSPs (n = 8). LVEF increased significantly over time in CON and IGF-1 MSPs (^a p < 0.05). At 10 weeks LVEF was significantly greater in IGF-1 MSPs compared to CON and MSPs (* p < 0.05). (C) Evolution of EDVi through the study in CON (n = 7), MSPs (n = 7) and IGF-1 MSPs (n = 8). EDVi (ml/m²) increased significantly over time in IGF-1 MSPs (^a p < 0.05). No significant differences between groups were seen. (D) Evolution of ESVi through the study in CON (n = 7), MSPs (n = 7) and IGF-1 MSPs (n = 8). No significant differences over time nor between groups were observed in ESVi (ml/m²). (E) Evolution of IS through the study in CON (n = 7), MSPs (n = 7) and IGF-1 MSPs (n = 8). Significant decreases over time were seen in all groups in IS (^a p < 0.05). No significant differences between groups were detected in this parameter.