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. 2020 Apr 28;10:7157. doi: 10.1038/s41598-020-64040-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A–F) Cell viability depending on small-molecule inhibitors of glutamine metabolism in cell lines indicated. Grey triangles indicate cells incubated in the presence of low Gln with high (dark grey) or low (light grey) N-Myc levels; rectangles and circles depict cells cultivated in the presence of high Gln with high (rectangles) or low levels (circles) of N-Myc. In experimental conditions indicated, high MYCN expression was induced by addition of tetracycline (“+ Tet”). (G) Scheme depicting the biochemical steps, in which the small molecule inhibitors of glutamine metabolism are supposed to act (AOA: aminoxyacetate; DON: 6-diazo-5-oxo-L-norleucine).