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. 2020 Apr 22;11:708. doi: 10.3389/fimmu.2020.00708

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Copyright © 2020 Zeng, Gu, Peng, Yang, Wang, Shi and Zou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A. baumannii-induced lethal pneumonia. Groups of C57BL/6 mice (n = 4–5) were intratracheally inoculated with 2.5 × 10⁶, 5 × 10⁶, and 2 × 10⁷ CFU of A. baumannii LAC-4. (A) The survival rates were monitored daily for 7 days. (B,C) Bacterial burdens (B) of lungs and blood, and histopathology (C) (200×) of lungs were detected at 4, 24, 48, and 72 hpi, respectively. Bacterial burdens are expressed as means ± SEM. “ND” means “not detect” due to mice death.