FIGURE 4.

Clampdown effect of HJ901 on cell survival and cytokine secretion in vivo. (A) Mice with TMD8 or U2932 xenografts were treated with or without HJ901 (10 or 25 mg/kg). (B) The tumor size of mice injected with TMD8 was observed at day 36. (C,D) Tumor volumes were measured every other day for 16 days. (E) Representative histological sections of the tumors were stained with hematoxylin and eosin (H&E) (magnification × 200 and 400). (F,G) Immunohistochemistry was used to detect the expression of Ki67 in tumor specimens. Similar results were obtained from three independent experiments. All data are presented as the means ± SEM (n = 5 in each group). *p < 0.05 and **p < 0.01 vs. PBS group.