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. 2020 Apr 28;10:7103. doi: 10.1038/s41598-020-63183-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Cerebral blood flow (CBF) reduction detected on MRI in hippocampus during acute (2d) and subacute (7d) hypoperfusion in BCCAS mice. The CBF drop at day 1 reaches 60–70% of the CBF values detected before the surgery (d0) or in naive mice and progressively recovers.CBF, cerebral blood flow; d, day; BCCAS, bilateral common carotid artery stenosis. (B) Differential gene expression, expressed in transcript per million (TPM) in APP-Aß metabolism genes and LOAD GWAS loci detected in BCCAS mice in hippocampus during subacute hypoperfusion (7d). C Percentage of ischemic lesion volume detected on T2-MRI in hippocampus of BCCAS mice during subacute hypoperfusion. H,hippocampus; L, left; R, right; d, day.