Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 28;10:7120. doi: 10.1038/s41598-020-63785-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Delivery in soft tissue models based on GelMA hydrogels. In all cases 0.5 pg of compound was dropped on acrylic thread and 100 μA was applied for electric field (unless specified otherwise). 5 mM Tris/HEPES buffer was used for both inlet/outlet chambers and GelMA. Error bars are based on the standard deviation of 3 replicates. (A) Speed of fluorescein (FL, a model compound) as a function of the stiffness (Young’s modulus). Trend line was y = −0.63 × +10.52, R-squared = 0.9912. Red dashed line represents the velocity at 0 crosslinking (11.2 ± 0.4 μm/s). (B) Representative pictures were taken for (i) 5% GelMA (45 s cross-link, stiffness of 4.3 kPa) at 100 μA, (ii) 7.5% GelMA (30 s cross-link, 7.9 kPa) at 100 μA, and (iii) 7.5% GelMA (60 s cross-link, 11.1 kPa) at 150 μA. Scale bar is 2.5 mm (C) Velocity of 5 different compounds and bioactive species: fluorescein (FL), rhodamine B (RhDB), riboflavin (RFN), BSA, dextran) in a GelMA hydrogel with a stiffness of 4.3 kPa, conditions were the same as Fig. 1. *Indicates significant different (P < 0.05). (D) Velocity as a function of the molecular weight of the compound. Speed in hydrogel declines with molecular weight following a trend of y = 4.02 × −0.57, R-squared = 0.9879.