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. 2020 Apr 28;10:7130. doi: 10.1038/s41598-020-64033-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proportion of the occurrence of signs for inadequate anesthesia. (A) increase in systolic blood pressure of more than 15 mmHg above the respective normal value in each patient (the lowest pressure measured at hospital admission), (B) heart rate greater than 90 beats/min in the absence of hypovolemia, (C) autonomic signs such as sweating, flushing, or lacrimation. When the increases in systolic blood pressure and heart rate occurred at the same time, the higher rate of increase was selected.