Table 1.
Characteristics of LDLR−/−ApoB100/100 Mice at the Time of Randomization (Week 0) and After 6-Week Treatment With Vehicle or X19-mu Antibody
| Week 0 | Vehicle | X19-mu | |
|---|---|---|---|
| Animals (f/m) | 11 (5/6) | 16 (8/8) | 16 (8/8) |
| Body weight (g) | 28 ± 5.1 | 30 ± 6.0 | 30 ± 7.7 |
| Blood glucose (mmol/l) | 11 ± 2.7 | 10 ± 2.6 | 10 ± 2.3 |
| Total cholesterol (mmol/l) | 29 ± 6.7 | 8.8 ± 1.6∗ | 9.0 ± 1.8∗ |
| LDL | 26 ± 6.3 | 6.8 ± 1.3∗ | 7.0 ± 1.6∗ |
| HDL | 5.9 ± 2.2 | 2.6 ± 0.67∗ | 2.8 ± 0.58∗ |
| Triglycerides (mmol/l) | 1.7 ± 0.52 | 1.5 ± 0.45 | 1.5 ± 0.53 |
Values are mean ± SD.
One-way analysis of variance with Dunnett's post-hoc test.
ApoB = apolipoprotein-B; F = female; HDL = high-density lipoprotein; LDL = low-density lipoprotein; LDLR = low-density lipoprotein receptor; M = male.
∗
p < 0.01 vs. week 0.