Table 3.
Recommended Medication Dose Titration Algorithm
| Clinical Assessment | Recommended Action |
|---|---|
| Normal BP (systolic BP ≥95 and ≤135 mm Hg) AND HR ≤90 beats/min AND QTc interval∗ <430 ms in men or <450 ms in women AND blood analysis within normality AND patient asymptomatic | Up titrate study medication in 50 mg/day |
| If the patient develops any of the following: significant hypotension (systolic BP <80 mm Hg) or hypertension (systolic BP >145 mm Hg) OR tachycardia (HR >100 beat/min) OR prolonged QTc interval∗ (>430 ms in men or >450 ms in women) OR worsening of renal function/transaminase elevation on blood analysis OR symptoms associated with medication | Reduce or stop study medication dose |
| If the patient presents with mild hypotension (systolic BP ≥80 and <90 mm Hg) OR mild hypertension (systolic BP >135 and ≤145 mm Hg) AND/OR HR 90−100 beats/min (with a QTc interval∗ <430 ms in men and <450 ms in women) AND blood analysis is within normality | Maintain study medication dose |