Table 1.
Echocardiographic parameters of sham and TAC mice.
| Parameter | Sham | TAC | ||||
|---|---|---|---|---|---|---|
| Vehicle | Vehicle | CUR 1 mg/kg | CUR 50 mg/kg | GO-Y030 0.1 mg/kg | GO-Y030 0.5 mg/kg | |
| LVPWd (mm) | 1.05 ± 0.12 | 1.73 ± 0.17** | 1.69 ± 0.09 | 1.43 ± 0.05## | 1.62 ± 0.11 | 1.31 ± 0.09##†† |
| IVSd (mm) | 1.24 ± 0.11 | 1.63 ± 0.12** | 1.62 ± 0.15 | 1.39 ± 0.11# | 1.53 ± 0.09 | 1.38 ± 0.09##† |
| LVIDd (mm) | 2.67 ± 0.26 | 2.83 ± 0.42 | 2.72 ± 0.31 | 2.66 ± 0.21 | 2.71 ± 0.22 | 2.67 ± 0.25 |
| LVIDs (mm) | 1.20 ± 0.27 | 1.81 ± 0.23** | 1.71 ± 0.27 | 1.30 ± 0.21## | 1.50 ± 0.36 | 1.27 ± 0.26## |
| LVMI (g/mg) | 4.1 ± 0.6 | 8.3 ± 1.5** | 8.0 ± 1.0 | 6.09 ± 0.8## | 7.3 ± 0.6 | 5.6 ± 0.9## |
| FS (%) | 55.6 ± 5.3 | 38.5 ± 7.8** | 39.2 ± 4.9 | 52.0 ± 5.1## | 46.1 ± 8.5 | 53.8 ± 6.1##†† |
*p < 0.05, **p < 0.01 vs. Sham + vehicle group.
#p < 0.05, ##p < 0.01 vs. TAC + vehicle group.
†p < 0.05, ††p < 0.01 vs. TAC + CUR 1 mg/kg group.
The values shown are the mean ± SEM for 6–7 mice from each of the sham and TAC groups.
Abbreviations: LVPWd, left ventricular posterior wall thickness; IVSd, interventricular septum thickness at end-diastole; LVIDd, left ventricular internal diameter end-diastole; LVIDs, left ventricular internal diameter end-systole; LVMI, left ventricular mass index; FS, fractional shortening